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Image Search Results
Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Article Title: Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies
doi: 10.1161/JAHA.124.035462
Figure Lengend Snippet: A , Schematic of the smoking system. Electronic cigarette and combustion cigarette aerosols were produced by the Mod‐Type E‐Cig Unit (a custom‐made system) and were pumped to a mixing chamber to be mixed with purified dilution air before entering the nose‐only exposure manifolds. Rats were confined in individual acrylic exposure tubes connected to the exposure manifold. A series of exhaust ports were provided for each rat's nose cone to promote the flow of new aerosol to the rat's breathing zone and to route expired breath to the exhaust port to prevent rebreathing and CO 2 buildup. B , Invasive hemodynamic measurement. Measuring and recording carotid pressure waveforms by 2F high‐fidelity piezo‐tipped micromanometer (Millar Mikro‐Cath Pressure Catheter). C , Visualization of the IF method throughout a full cardiac cycle. Each of the systolic and diastolic phases is illustrated within a circle via their corresponding intrinsic frequency ω 1 or ω 2 and the corresponding intrinsic envelope (R s or R d ). The parameters θ s and θ d are the intrinsic phases during systole and diastole, respectively, and d θ /d t is the instantaneous frequency. D , Sample IF‐based reconstruction of a carotid waveform. Sample of an original raw carotid waveform (dashed black) overlaid on top of the IF‐based reconstructed waveform (blue). 𝜔 1 indicates first intrinsic frequency; 𝜔 2 , second intrinsic frequency; and IF, intrinsic frequency.
Article Snippet: The major steps of our rat experimental surgeries are summarized as (1) full anesthesia (described earlier in this section), (2) intubation and mechanical ventilation, (3) neck incisions to expose and isolate the right carotid artery and jugular vein (the rat's body was positioned appropriately in the lateral recumbency, and corresponding cutdowns were performed), (4) insertion of a 2F high‐fidelity piezo‐tipped
Techniques: Produced, Purification, Aerosol